Injectable microspheres to repair failing hearts after a heart attack

Article By: Lisa Jones British Heart Foundation (BHF) - READ ORIGINAL ARTICLE

Heart Failure

Injectable microspheres to repair failing hearts after a heart attack

Researchers have developed biodegradable microspheres that can be used to deliver heart cells generated from stem cells to repair damaged hearts after a heart attack

This type of cell therapy could one day cure debilitating heart failure, which affects an estimated 920,000 people in the UK and continues to rise as more people are surviving a heart attack than ever before.

Scientists have been trying to use stem cells to repair damaged hearts for a number of years. However, these cells often don’t remain in the heart in a healthy state for long enough to provide a sustained benefit.

Now, the team at University College London (UCL) have grown human stem cell-derived heart cells on tiny microspheres, each only a quarter of a millimetre wide, engineered from biological material. The cells attach to and grow on the microspheres, make connections with each other and are able to beat for up to 40 days in a dish. The small size of the microspheres means they can be easily injected into the heart muscle using a needle.

State-of-the-art technology
The researchers have also taken this one step further by developing state-of-the-art technology to visualise the injected microspheres and confirm they remain in place. Barium sulphate (BaSO4), which shines bright on X-rays and CT scans, was added to the microspheres and injected into rat hearts. Whole body CT scans confirmed that the microspheres remained in place for up to 6 days after injection.

The researchers say this technology could provide the next generation of materials to effectively deliver new cells to failing hearts to restore their function, and hope it will be tested in human clinical trials in the next 10 years.

One step closer to heart failure cure
Dr Daniel Stuckey, BHF Intermediate Research Fellow at UCL Centre for Advanced Biomedical Imaging, said:

“To truly mend broken hearts, it is important that stem cells are delivered in a way that allows them to survive within their new environment and turn into heart muscle cells. Our technology provides a new way of ensuring that the cells injected into the heart are working as they should. We hope this research will give us the information essential for making stem cell therapy a realistic treatment for people with heart disease."

Professor Metin Avkiran, our Associate Medical Director, said:

“This is a promising new delivery system that could give stem cell-derived heart cells the best chance of repairing damaged hearts. After a heart attack, heart muscle tissue becomes damaged and has a limited ability to heal itself, increasing a person’s chance of developing heart failure.

“Breakthroughs like this bring us closer to finding much-needed cures for heart failure and provide light at the end of the tunnel for the hundreds of thousands of people living with this debilitating condition.”


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